I have both sealed and opened copies of my games, depending how much I love the francise. For example, I have a sealed copy of the Dead Space Ultra edition which cost me a small fortune. I won't open that in case I ever want to sell it (which I doubt).
I also have sealed copies of Demon's Souls Deluxe, Dark Souls & DS2.
The majority of my CE's I open though and enjoy. I store the box, etc away to keep it as minty fresh as possible. Space is running out though...